Oral immunotherapy induces clinical tolerance in peanut-allergic children

An American study has been carried out to determine if peanut oral immunotherapy (OIT) induces immunological peanut tolerance in allergic children, and whether it is possible to identify any predictors of clinically tolerant children.

Nine children aged between 25 – 65 months were included in the study and had completed maintenance OIT. They underwent a series of food challenges. After 33-41 months of OIT four children passed a second oral food challenge (OFC), and then another OFC after stopping OIT for four weeks.

These four children now have peanuts as a part of their daily diet, and are considered clinically tolerant. These subjects had significantly lower baseline levels of peanut IgE than the other five, and all levels of peanut IgE decreased steadily throughout the trial.

Source: Journal of Allergy and Clinical Immunology

First published in March 2009

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