Test to establish whether a milk-allergic child can tolerate heated milk

Earlier research (published in J Allergy Clin Immunol 2008; 122:342-347.e2) reported that up to 75% of children with milk allergy can tolerate heated milk but how are parents to tell if their child is one of those 75%?

However a study at the Jaffe Food Allergy Institute, Mount Sinai School of Medicine in New York showed that Immunoglobulin E (IgE) antibodies from children who reacted to all forms of milk products (baked milk and unheated milk) bound to more epitopes than children who reacted only to unheated milk. In addition, the severity of the reaction directly correlated with the number of epitopes recognized by IgE antibodies from a child.

Researchers hope that this blood test will enable them to tell which cow's milk-allergic children will be able to tolerate milk in baked products without having to resort to oral food challenges and may also provide some insight into the severity of allergic reaction that a patient might experience.

The study was reported at the 2010 Annual Meeting of the American Academy of Allergy, Asthma & Immunology.

Wang J, et al "Correlation of IgE and IgG4 milk epitopes with different clinical phenotypes of milk allergy using microarray immunoassay" AAAAI 2010; Abstract 229.
Lin J, et al "Correlation of IgE affinity with different clinical phenotypes of milk allergy" AAAAI 2010; Abstract 89.

For a longer reports see MedPage Today

First published February 2010


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