In case reports published in Urology last year, two patients were referred for evaluation of male infertility. They were shown to have changes in sperm motility and/or concentration related to antidepressant use.

Initially, analysis of the semen specimens showed low semen volume and impaired movement, and abnormal size and shape of sperm. In both cases, they were taking serotonin re-uptake inhibitors. (Examples of this type of medication: Prozac, Zoloft, Paxil, Lexapro, Celexa.)
One to two months after discontinuing the antidepressants, there was improvement in sperm concentration and motility.

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Courtesy of Latitudes
www.latitudes.org

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First Published in December 2008

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