Prenatal phthalate exposure associated with ADHD disorders

Engel SM, Miodovnik A, Canfield RL, Zhu C, Silva MJ, Calafat AM, et al. 2010. Prenatal Phthalate Exposure is Associated with Childhood Behavior and Executive Functioning.
Environ Health Perspect :-. doi:10.1289/ehp.0901470

Background:
Experimental and observational studies have reported biological consequences of phthalate exposure relevant to neurodevelopment.

Objective:
To examine the association of prenatal phthalate exposure with offspring behavior and executive functioning at ages 4 to 9 years.

Methods:
The Mount Sinai Children’s Environmental Health Study enrolled a multiethnic prenatal population in New York City between 1998 and 2002 (n= 404). Third trimester maternal urines were collected and analyzed for phthalate metabolites. Children (n = 188, n = 365 visits) were assessed for cognitive and behavioral development between the ages of 4 and 9 years.

Results:
In multivariate adjusted models, increased loge concentrations of low molecular weight (LMW) phthalate metabolites were associated with poorer scores on the Aggression (β = 1.24, 95% Confidence Interval [CI] 0.15, 2.34), Conduct Problems (β = 2.40, 95% CI 1.34, 3.46), Attention Problems (β = 1.29, 95% CI 0.16, 2.41), and Depression (β = 1.18, 95% CI 0.11, 2.24) clinical scales; and Externalizing Problems (β = 1.75, 95% CI 0.61, 2.88) and Behavioral Symptom Index (β = 1.55, 95% CI 0.39, 2.71) composite scales. Increased loge concentrations of LMW phthalates were also associated with poorer scores on the Global Executive Composite index (β = 1.23, 95% CI 0.09, 2.36), and the Emotional Control scale (β = 1.33, 95% CI 0.18, 2.49).

Conclusion:
Behavioral domains adversely associated with prenatal exposure to LMW phthalates in our study are commonly found to be affected in children clinically diagnosed with Conduct or Attention-Deficit Hyperactivity Disorders.

First published in January 2010

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